B-cell development: BCL-6 recruits new team member

BCL-6 expression during B-cell activation.

Translocations involving the BCL-6 gene are common in the diffuse large cell subtype of non-Hodgkin's lymphoma. Invariably, the BCL-6 coding region is intact, but its 5' untranslated region is replaced with sequences from the translocation partner. The present study shows that BCL-6 expression is regulated in lymphocytes during mitogenic stimulation. Resting B and T lymphocytes contain high lev...

Clonal B-cell lymphocytosis: a new member?

Telematik Newsletter News New Team Member Sören Finster Figure 1 New Team Member: Sören Finster

Since September, Sören Finster (Fig. 1) is a memeber of the institute of telematics. In context of the E-Energy project MEREGIO he is studying distributed approaches for information and communication technology in future energy systems. He wrote his diploma thesis at the system architecture group with the topic “Design and Implementation of Energy Containers in TinyOS” at University of Karlsruhe.

Regulatory B cell: New member of immunosuppressive cell club.

Historically, the pivotal role of B cells or B lymphocytes in immunity has been attributed to the production of antibodies. They were also demonstrated to present antigens to T cells and to secrete cytokines, thereby acting as positive regulators in immune responses. A series of studies on autoimmune diseases, however, led researchers to find a unique subset of B cells, later described as "regu...

Large B - Cell Lymphoma Clinical Relevance of BCL 2 , BCL 6 , and MYC Rearrangements in Diffuse

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